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Antioxidant Flavonols – From Fruit, Tea and Wine – Linked to Slower Reminiscence Decline

A brand new examine discovered that individuals who eat or drink extra meals with antioxidant flavonols could have a slower price of reminiscence decline as they age.

Based on new analysis, individuals who eat or drink extra meals with antioxidant flavonols, that are present in tea and wine in addition to a number of fruit and veggies, could have a slower price of reminiscence decline. The examine was printed within the November 22, 2022, on-line challenge of Neurologythe medical journal of the American Academy of Neurology.

“It is thrilling that our examine exhibits making particular food plan decisions could result in a slower price of cognitive decline,” mentioned examine writer Thomas M. Holland, MD, MS of Rush College Medical Heart in Chicago. “One thing so simple as consuming extra fruit and veggies and ingesting extra tea is a simple means for individuals to take an energetic function in sustaining their mind well being.”

Flavonols are a kind of flavonoid, a gaggle of phytochemicals present in plant pigments recognized for his or her helpful results on well being.

Individuals within the examine included 961 individuals with out dementia with a median age of 81. They stuffed out a questionnaire annually on how typically they ate sure meals. In addition they accomplished annual cognitive and reminiscence assessments together with recalling lists of phrases, remembering numbers and placing them within the appropriate order. They have been additionally requested about different elements, reminiscent of their stage of training, how a lot time they spent doing bodily actions and the way a lot time they spent doing mentally partaking actions reminiscent of studying and taking part in video games. They have been adopted for a median of seven years.

Researchers divided the individuals into 5 equal teams primarily based on the quantity of flavonols they’d of their food plan. Whereas the common quantity of flavonol consumption in US adults is about 16 to twenty milligrams (mg) per day, the examine inhabitants had a median dietary consumption of complete flavonols of roughly 10 mg per day. The bottom group had an consumption of about 5 mg per day and the best group consumed a median of 15 mg per day; which is equal to about one cup of darkish leafy greens.

“One thing so simple as consuming extra fruit and veggies and ingesting extra tea is a simple means for individuals to take an energetic function in sustaining their mind well being.” — Thomas M. Holland, MD, MS

To find out charges of cognitive decline, researchers used an general international cognition rating summarizing 19 cognitive assessments. The common rating ranged from 0.5 for individuals with no considering issues to 0.2 for individuals with delicate cognitive impairment to -0.5 for individuals with[{” attribute=””>Alzheimer’s disease.

After adjusting for other factors that could affect the rate of memory decline, such as age, sex and smoking, researchers found that the cognitive score of people who had the highest intake of flavonols declined at a rate of 0.4 units per decade more slowly than people whose had the lowest intake. Holland noted this is probably due to the inherent antioxidant and anti-inflammatory properties of flavonols.

The study also broke the flavonol class down into the four constituents: kaempferol, quercetin, myricetin and isorhamnetin. The top food contributors for each category were: kale, beans, tea, spinach and broccoli for kaempferol; tomatoes, kale, apples and tea for quercetin; tea, wine, kale, oranges and tomatoes for myricetin; and pears, olive oil, wine and tomato sauce for isorhamnetin.

People who had the highest intake of kaempferol had a 0.4 units per decade slower rate of cognitive decline compared to those in the lowest group. Those with the highest intake of quercetin had a 0.2 units per decade slower rate of cognitive decline compared to those in the lowest group. And people with the highest intake of myricetin had a 0.3 units per decade slower rate of cognitive decline compared to those in the lowest group. Dietary isorhamnetin was not tied to global cognition.

Holland noted that the study shows an association between higher amounts of dietary flavonols and slower cognitive decline but does not prove that flavonols directly cause a slower rate of cognitive decline.

Other limitations of the study are that the food frequency questionnaire, although valid, was self-reported, so people may not accurately remember what they eat.

Reference: “Association of Dietary Intake of Flavonols With Changes in Global Cognition and Several Cognitive Abilities” by Thomas Monroe Holland, Puja Agarwal, Yamin Wang, Klodian Dhana, Sue E. Leurgans, Kyla Shea, Sarah L Booth, Kumar Rajan, Julie A. Schneider and Lisa L. Barnes, 22 November 2022, Neurology.
DOI: 10.1212/WNL.0000000000201541

The study was supported by the National Institutes of Health, National Institute on Aging, and USDA Agricultural Research Service.

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